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SARMS are a group of synthetic drugs that mimic the effects of testosterone in muscle and bone with minimal impact on other organs and reduced side effects COMPARED to that of anabolic agents, such as anabolic steroids (which are often used in competition) SARMS have been reported to be more effective. A review was done in 2002 by a team from the National Institute of Health (NIH) with support from the FDA and reviewed in detail the information from several studies on the effectiveness of SARMS compared to other agents and steroids. The reviewers concluded that while SARMS had only modest advantages over performance-enhancing drugs (PED's), the evidence was sufficient to warrant use of SARMS. The review did not address the effectiveness of SARMS in preventing cardiovascular disease (CVD) or other life-threatening outcomes. The US Food and Drug Administration (FDA) issued its decision on August 3, 2016; the public is now allowed to import SARMS. SARMS use in humans is still limited to the athletic training of those participating in athletics. It is now unclear whether SARMS have an effect on human athletes such as Olympic athletes to which the FDA did not require the risk evaluation to include in their decision. It remains unclear how the SARMS may affect the development of the human body. FDA's decision to limit SARMS use to athletic training will likely continue as the company expands to new markets including anti-aging and anti-cancer medicine. In 2014, the company reported that its revenues had been greater than $2.3 billion in 2015 and it had grown from $20 million in 2012. This led the company to have expanded production of SARMS to include products ranging from weight loss creams, to body washes, to anti-ageing creams. The company has recently increased its marketing of SARMS to healthcare service providers including physicians, hospitals, and pharmacies. A February 2017 report published by the National Cancer Institute (NCI) concluded that the use of SARMs for the treatment of aging men was effective, as assessed based on the literature reviews and reviews on efficacy. A February 2017 FDA press release published a study titled "Use of SARMs among male athletes to enhance physical performance and the reduction of age-related changes as measured by MRI" that found evidence of a positive safety effect. The study did not examine acute adverse events, which are the type of adverse events that are the focus of the FDA's concern and a topic of much discussion. There were a few reported adverse events, however they did not meet the criteria for an immediate warning, and the study did not report any adverse events related to the specific anti-aging ingredient Related Article: